Transfection of dendritic cells (DCs) with the CIITA gene: increase in immunostimulatory activity of DCs
نویسندگان
چکیده
منابع مشابه
Gap junction-mediated intercellular communication between dendritic cells (DCs) is required for effective activation of DCs.
Gap junctions, formed by members of the connexin (Cx) family, are intercellular channels allowing direct exchange of signaling molecules. Gap junction-mediated intercellular communication (GJIC) is a widespread mechanism for homeostasis in organs. GJIC in the immune system is not yet fully understood. Although dendritic cells (DC) reportedly form cell-to-cell contact between DCs in nonlymphoid ...
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In this study, Ealpha green fluorescence protein (EαGFP)/YAe system was used to visualize antigen uptake and presentation by BMDCs [12,14] (Figure 1). This system allows assessment of antigen uptake/degradation and, in combination with the YAe antibody antigen presentation in situ [12,14,15]. When this antigen is internalized by DCs, EαGFP is degraded and the Eα peptide is presented by IAbMHCII...
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ژورنال
عنوان ژورنال: Cancer Gene Therapy
سال: 2001
ISSN: 0929-1903,1476-5500
DOI: 10.1038/sj.cgt.7700292